PDK1 and neoplasm: We also found that the transcript levels of certain key glycolytic pathway enzymes varied between PDAC subtypes: these included the transcript levels of pyruvate kinase (PKM), lactate dehydrogenase (LDHA) and pyruvate dehydrogenase complex kinase-1 (PDK1) which were highest in C-PDAC tumours and lowest in EL-PDAC tumours (Figure 3B).