NFKB1 and neoplasm: The p53 network, on the other hand, was more prominent in C-PDAC and EL-PDAC tumours, and it connected signalling proteins to various TFs that are known to promote carcinogenesis, including ATF3, PRKCD, NFKB1 and NFKBIA [53–55].These TFs were also predicted by PARADIGM to have a high degree of activity (Figure 6B).