Alterations, included the activation of, among others, the PI3KCA (in 13% of tumours), AKT (in 27%) and BRAF (in 9%) genes, and the inactivation of the PTEN (in 4% of tumours), TSC1/2 (in 7%) and FOXO3 (in 5%) genes. Here, FOXO3 is linked to neoplasm.