For example, S100A4 is involved in autoimmune pancreatitis [48], S100A11, S100A8 and S100A9 in rheumatoid arthritis [49, 50], S100A1 in hypoxia-induced inflammatory response in cardiomyocytes [51], S100A12 in Crohn’s disease [52], S100A7 and S100A7A in psoriasis [53], S100A8, S100A9 and S100A12 in systemic lupus erythematosus [54]. The gene discussed is S100A4; the disease is rheumatoid arthritis.