Several studies have shown that pro-inflammatory mediators, such as interleukin (IL)6, IL8, and tumor necrosis factor (TNFα), are elevated in oral cancer patients [6–8] and in the saliva of patients with pre-neoplastic oral lesions [9] but the mechanisms by which inflammation modulates oral cancer behavior are mostly unknown. The gene discussed is TNF; the disease is lip and oral cavity carcinoma.