KRAS and neoplasm: In addition, the presence of nodal micrometastases in bi- or trimutated CRCs indicates disease diffusion in spite of pTNM stage I. Different from our previous study [24] on a cohort of CRCs at pTNM stages I, II, III, and IV, the presence of a single KRAS mutation was not associated with PDC grade or tumor budding in this group of pTNM stage I CRCs.