PIK3CA and neoplasm: Univariate analyses showed that high PDC grade (P = 0.0112), the presence of tumor budding (P = 0.0334), LVI (P < 0.0001), KRAS mutations (P = 0.0228), PIK3CA mutations (P = 0.0214), multiple genetic mutations in KRAS and PIK3CA genes (P = 0.039) (Figure 2), and nodal micrometastases (P < 0.0001) (Figure 2(b)) were significant prognostic variables for CSS (Table 4).