Rivoltini et al. showed that exosomes derived from K562 leukemia cells modified with TNF-related apoptosis-inducing ligand (TRAIL) [TRAIL(+) exosomes], induced apoptosis in TRAIL-death receptor (DR)5(+) SUDHL4 lymphoma and INT12 melanoma cells in vitro. Here, TNFSF10 is linked to melanoma.