ANXA5 and infection: Consistent with literature, we also observed Mtb infection to cause necrosis instead of apoptosis of THP1 macrophages with poor Annexin V staining (1–15%, N = 3) and efficient PI staining (20–85%, N = 3) within 8 h of infection at MOI 50 (Figure 4A; Figures S3A,B in Supplementary Material).