The association between COMT rs4818 and treatment response to risperidone was also reported in 288 Shanghai patients with schizophrenia (Shi et al., 2017), but opposed to our and their previous (Xu et al., 2015) results, the G/C allele frequency was similar between good and poor responders (Shi et al., 2017). The gene discussed is COMT; the disease is schizophrenia.