If this finding will be confirmed in larger studies and meta-analyses, women with schizophrenia who are carriers of the COMT rs4680 and rs4818 low-activity haplotypes, might require different treatment approach, such as early clozapine initiation (Siskind et al., 2017), clozapine augmentation with different antiepileptic drugs (Zheng et al., 2017), or electroconvulsive therapy (ECT) (Vuksan et al., 2018). Here, COMT is linked to schizophrenia.