Previously observed association between COMT rs4680 and schizophrenia (Egan et al., 2001; González-Castro et al., 2016) was not confirmed in a meta-analysis (Munafo et al., 2005), or in a cohort with large number of ethnically homogeneous Caucasians in our previous study (Nikolac et al., 2013). Here, COMT is linked to schizophrenia.