COMT and depressive disorder: However, sexual dimorphism of COMT gene has been also reported in various neuropsychiatric disorders such as anxiety disorders, depression, attention deficit hyperactivity disorder, and obsessive-compulsive disorder (Karayiorgou et al., 1997, 1999; Domschke et al., 2004, 2007; Poyurovsky et al., 2005; Denys et al., 2006; Rothe et al., 2006; Pooley et al., 2007; Cao et al., 2014; Akutagava-Martins et al., 2016).