TARDBP and amyotrophic lateral sclerosis: By using this approach, Armstrong et al. (2016) generated a zebrafish model of amyotrophic lateral sclerosis (ALS), via insertion of two SNPs in the zebrafish tardbp and fus genes (tardbpA379T and fusR536H, respectively), corresponding to tardbpA382T and fusR521H disease-causing point mutations identified in patients with ALS (Armstrong et al., 2016) (Table 1).