In the infralimbic medial prefrontal cortex, STDP is absent in a rodent model (BDNF-Met/Met mice) of the human BDNF Val66Met polymorphism (leading to severe cognitive dysfunction and anxiety disorders) in which the BDNF release is impacted; STDP is recovered after exogenous BDNF application (Pattwell et al., 2012). This evidence concerns the gene BDNF and anxiety disorder.