Amplifications of chromosome 5p (rapamycin-insensitive binding partner of mTOR, CDH9, LIFR) and 1p/1q (PI4KB, ETV3, MCL1), and deletions of tumor-suppressor genes including CDKN2A/B and TP53, have been reported in MFS, as have loss-of-function mutations in NF1 (5/35) and PTEN (1/35)7. This evidence concerns the gene TP53 and Marfan syndrome.