CD47 and neoplasm: Importantly, in addition to the changes detected in immune cells, interesting observations could be made on tumor cells simultaneously, including well-described IFN-γ induced upregulation of HLA class I expression27, downregulation of the anti-phagocytic protein CD47 [ref.28] or upregulation of the programmed cell death receptor CD95, also termed FasR [ref.29] on these cells (Fig. 5C).