In this model, loss of stromal PTEN hyperactivates the transcription factor ETS2 (v-Ets avian erythroblastosis virus E26 oncogene homologue 2), ultimately generating an oncogenic secretome, and increasing extra-cellular matrix (ECM) remodeling, immune cell infiltration, and tumor vascularization3,6. This evidence concerns the gene PTEN and neoplasm.