Quinn et al. 44 have recently reported that CAP1 co-immunoprecipitates several adenylyl cyclase (AC) isoforms (at least AC1, 3, 4 and 7) in pancreatic cancer cells and forms an AC3/CAP1/G-actin complex upon stimulation with forskolin that inhibits cell motility. Here, CAP1 is linked to familial pancreatic carcinoma.