HMGA2 and cancer: The mammalian high mobility group protein (HMGA2, MW ~12 kDa), an intrinsically disordered protein (IDP) that aids in the regulation and expression of certain genes by influencing the remodeling of chromatin structure1–3, is also a known oncofetal antigen1,4, biomarker of cell transformation and metastasis5,6, and a target in cancer therapeutics7,8.