MPO and colitis: Moreover, the hydroalcoholic extract (50, 100 and 200 mg/kg) and its chloroform fraction (100 and 200 mg/kg) from M. oleifera seeds showed therapeutic effects in Wistar rats with acetic acid-induced colitis, even causing a significant reduction of ulcer severity, area and index as well as on mucosal inflammation severity and extent, crypt damage, invasion involvement, total colitis index and myeloperoxidase activity [47].