CD274 and neoplasm: Currently, the only predictive biomarkers used to select GC patients for targeted immunotherapy, i.e., Pembrolizumab (anti-PD-1 antibody) [15,16,17] are MSI-high status and/or the expression of PD-L1 by immunohistochemistry (IHC) in cancer epithelial cells and/or in immune cells of the tumor microenvironment.