GRP78 adenoviruses infection efficiency in the VMH was assessed by the expression of GFP [4,17,23,24,25,26,27,30], and by increased concentrations of GRP78 (which was higher in the vHFD rats, likely due to the greater basal levels [23]) and reduced ER stress in the VMH, reducing the protein levels of pPERK, pIRE1α, ATF6α, and peIF2α in the VMH of STD rats (Figure 1E) while decreasing pPERK, ATF6α, peIF2α, and CHOP vHFD rats (Figure 1F). This evidence concerns the gene HSPA5 and infection.