In addition, the circular isoform of the coding gene Itchy E3 Ubiquitin Protein Ligase (ITCH), cir-ITCH functions as a sponge for miR-7, miR-17, and miR-214 in esophageal squamous cell carcinoma (ESCC). This evidence concerns the gene UBE2E3 and esophageal squamous cell carcinoma.