One hour after infection, host proteins identified to associate with viral DNA include the catalytic subunit of host polymerase (Pol) II (POLR2A), factors that play roles in transcription regulation and RNA processing (INTS1, USP39, SRRT, DDX23, and THOC7), core components of PML NBs (PML, SP100, and SUMO2), factors involved in the regulation of chromatin structure (HP1BP3, HIST1H1A, HIST1H1E, CHD4, CSNK2A1, SUPT16H, SMARCC2, SMARCA4, and TRRAP), and factors that are recruited to damaged DNA (PARP1, PARP14, RPA1, and ligase 3 [LIG3]). The gene discussed is LIG3; the disease is infection.