In addition, both S. homoeocarpa CYPs and human CYP3A enzymes have the ability to detoxify propiconazole (20), and upregulation of CYPs and ABC transporters by ShXDR1/PXR is a main factor for multidrug resistance in S. homoeocarpa and human cancer (9, 33, 34). Here, CYP3A4 is linked to cancer.