Mutations in the E3 ligases MDM2, BRCA1, TRIMs, and Parkin have been linked to multiple cancers and neurodegenerative diseases (Fakharzadeh et al., 1991, Hatakeyama, 2011, Welcsh and King, 2001), and MDM2-p53 interaction inhibitors have already been developed as a potential anti-cancer treatment (Shangary and Wang, 2009). The gene discussed is MDM2; the disease is cancer.