Until now, we established a positive feedback loop between PBX3 and let-7b, which involves MEK/ERK1/2, c-myc and LIN28, and ultimately affects HMGA2 and IL-6/STAT3 pathways to promotes GBM mesenchymal transition, migration and invasion (Fig. 6g). The gene discussed is HMGA2; the disease is glioblastoma.