We found that Ube2v1 promotes EMT of CRC cells as demonstrated by decreased expression of E-cadherin, as well as increased expressions of β-catenin, Vimentin, Fibronectin, N-cadherin, Snai1, and Twist1 following Ube2v1 overexpression in DLD-1 and SW480 cells (Fig. 4a). Here, TWIST1 is linked to colorectal carcinoma.