EGFR and cancer: For identifying whether Lycorine is a novel potential EGFR inhibitor for cancer therapy, we downloaded the X-ray crystal structure of EGFR kinase domain from the Protein Data Bank (PDB ID: 5FED, EGFR kinase domain in complex with a covalent aminobenzimidazole inhibitor), and AutoDock Toolkit (ADT) software package was employed to perform the molecular docking assay.