In conclusion, results of Fig. 3b suggested that the inhibition effect of Lycorine to GBM cells were correlated with the expression amount of EGFR, no matter wild type EGFR, or EGFRvIII, or other EGFR mutants, thus Lycorine could be considered a candidate to overcome different EGFR mutation status in treating GBM. Here, EGFR is linked to glioblastoma.