CYP3A4 and glioblastoma: Particularly important, Lycorine is an agent that can effectively penetrate the blood-brain barrier (BBB) and doesn’t induce obvious CYP3A4 inhibitory activity [22], which means that GBM primary tumors in the cranial cavity can be easily accessible by Lycorine administration through oral intake or intravenous injection without systemic hepatotoxicity.