As UGT1A is involved in Ara-C detoxification, we hypothesized that the functional polymorphisms in UGT1A1 may affect chemosensitivity to Ara-C based therapies in AML patients through influence Ara-C metabolism, which could eventually improve responses to Ara-C and AML prognosis. The gene discussed is UGT1A1; the disease is acute myeloid leukemia.