As already mentioned, it was also shown that ANP can stimulate the proliferation of cultured rat pancreatic islets β-cells and insulinoma cells (INS-1E) via GC-A/cGMP-dependent activation of phosphatidylinositol 3′-kinase and Akt/Foxo1a/cyclin-D2 signaling [16]. This evidence concerns the gene FOXO1 and pancreatic insulinoma.