We suggest that the ABCB1 rs1045642 T allele and rs2235048 C allele decrease sympathetic and total nervous activity system in patients with schizophrenia treated with aripiprazole and that ABCB1 rs1045642 and rs2235048 and the ABCB1 haplotype (rs1045642-rs2235048-rs1128503-rs2032582) could affect the tolerability of aripiprazole and aripiprazole-induced ANS dysfunction. The gene discussed is ABCB1; the disease is schizophrenia.