Saxagliptin, compared with GLP-1 agonists, reduced HF hospitalization by 26% (HR, 0.74; 95% CI 0.69, 0.84), whereas sitagliptin reduced HF hospitalization by 8% (HR, 0.92; 95% CI 0.89, 0.95) compared to GLP-1 agonists. Here, GLP1R is linked to hydrops fetalis.