FBN1 and geleophysic dysplasia: The importance of fibrillin-1 in the function of tissues is further highlighted by fibrillin-1 mutations that cause a number of heritable connective tissue disorders termed fibrillinopathies, such as Marfan syndrome (MFS) [5], Weill Marchesani syndrome (WMS) [6] and geleophysic dysplasia (GD) [7].