MATR3 and amyotrophic lateral sclerosis: Given previously established relationships between the distribution and aggregation of RBPs and neurodegeneration in ALS models (Johnson et al., 2009; Barmada et al., 2010b; Dormann et al., 2010; Igaz et al., 2011; Kim et al., 2013; Qiu et al., 2014), we wondered whether the enhanced toxicity of pathogenic MATR3 variants arises from mutation-associated changes in MATR3 localization or solubility.