Moreover, over 40 different ALS-associated mutations have been identified in the gene encoding TDP-43, and mutations in several different RBPs have been similarly linked to familial ALS (Kabashi et al., 2008; Kwiatkowski et al., 2009; Vance et al., 2009; Barmada and Finkbeiner, 2010a; Ticozzi et al., 2011; Kim et al., 2013). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.