Pathogenic mutations in the genes encoding TDP-43 and related RBPs, including FUS and TIA1, shift the equilibrium towards irreversible phase separation and the formation of cytoplasmic aggregates analogous to those observed in post-mortem tissues from patients with ALS (Johnson et al., 2009; Patel et al., 2015; Gopal et al., 2017; Mackenzie et al., 2017). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.