Conversely, we noted a significant increase in the risk of death for cells expressing high levels of MATR3-EGFP (Figure 1H); this relationship is similar to that observed for other proteins associated with neurodegenerative disorders, including TDP-43 (ALS/FTD; Barmada et al., 2015) and mutant huntingtin (Huntington’s disease; Miller et al., 2010). Here, MATR3 is linked to frontotemporal dementia.