Growing evidence suggest that hypoxia affects the expression of GTs in tumor cells, including human colon cancer cell lines SW480, C1 and Colo20, where a 7-day exposure to hypoxia was shown to increase the transcription of genes encoding for FUT7, ST3Gal-I and UDP-galactose transporter-1 (UGT1) [45]. Here, ST3GAL1 is linked to neoplasm.