CCK and pancreatitis: To test if the ability of Arid1a suppression to accelerate Kras driven preneoplastic transformation is due to a defect in acinar regeneration, we challenged C-RIK-shArid1a or C-RIK-shRen mice with pancreatitis induced by the cholecystokinin analog caerulein (Strobel et al., 2007).