EGF and hepatocellular carcinoma: Elevated expression of CXCL5 was found in diverse tumor entities including HCC, thereby correlating with poor prognosis of patients.29 Zhou et al. suggested that CXCL5 promotes HCC cell proliferation, invasion, and intratumoral neutrophil infiltration.7 It was further demonstrated that EGF/EGFR stimulates CXCL5 production in HCC through PI3K and MAPK signaling.