From these genes, we focused on CXCL5, which belongs to the CXC chemokine family that is also known as epithelial‐derived neutrophil‐activating peptide 78, binding primarily to the chemokine receptor CXCR2.20 Most notably, we found that CXCL5 is regulated by the collaboration of TGF‐β and Axl signaling to facilitate neutrophil infiltration in HCC patients. Here, CXCR2 is linked to hepatocellular carcinoma.