HTR1A and phobic disorder: CBD has long been proposed to inhibit THC-associated anxiety by antagonizing cannabinoid receptor activation by THC.61–63 CBD may also reduce anxiety via the serotonin 5-HT1A and/or GABAA receptors.14,64 These receptor pathways are being explored in hopes of novel therapeutic strategies for phobias, post-traumatic stress disorder, and drug abuse.65,66