The following small molecular compounds also directly regulate NR4A1 activity in different cells: 1,1-bis(3′-indolyl)-1-(p-hydroxyphenyl)methane (DIM-C-pPhOH) and the related p-carboxymethylphenyl (1,1-bis(3′-indolyl)-1-(p-carboxymethylphenyl)methane (DIM-C-pPhCO2 Me)) analogs, which bind NR4A1 to inhibit growth and induce apoptosis in several cancer cell lines and tumors from mouse xenografts [49, 50]. The gene discussed is NR4A1; the disease is cancer.