Besides, pathways related to obesity, such as insulin signaling pathway and nonalcoholic fatty liver disease, are also enriched in epitranscriptome module M2, suggesting a possible relationship with FTO, which is the first obesity-related gene identified from GWAs analysis [48] and the first known RNA m6A demethylase [49]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.