Early after infection in mice experimental model, most of the parasites appear to be phagocytized by splenic macrophages and mature DC start producing IL-12 or IL-23 to initiate protective Th1 or Th17 responses, respectively, which, in turn, will produce IFNγ, TNF or IL-17 that maximize the capacity of infected macrophages to produce NO and ROS (reviewed in Rodrigues et al., 2016). This evidence concerns the gene IFNG and infection.