As TMZ induces autophagy and HIF-1α possesses the KFERQ-like target motif needed for CMA degradation (29, 30), we hypothesized (and have subsequently demonstrated) that inhibiting CMA by silencing LAMP-2A not only inhibits HIF-1α downmodulation in sensitive GBM cells but it is also correlates with their acquisition of “TMZ-resistant behavior.” The gene discussed is HIF1A; the disease is glioblastoma.