HIF-1α is also an important prognostic indicator in clear cell renal carcinoma (50) and recent studies have shown that it plays a role in the pathophysiological evaluation of gliomas as HIF-1α silencing combined with radiation therapy increases the therapeutic efficacy of glioma treatment by regulating cell cycle- and apoptosis-related signaling pathways (51, 52). The gene discussed is HIF1A; the disease is clear cell renal carcinoma.