RAP1B (P < 0.001), BRAF (P < 0.05), MEK2 (P < 0.001), ERK1 (P < 0.001), ERK2 (P < 0.01), ETS1 (P < 0.001) and ETS2 (P < 0.001) were enhanced in ccRCC compared with normal renal tissues (Fig. 4). The gene discussed is MAP2K2; the disease is nonpapillary renal cell carcinoma.