However, this hypothesis was not explored in this study and remains untested.40 In line with this finding, SETD7 increases the stability and transcriptional activity of ERα,29 a marker associated with luminal gene expression signatures.220 Consistent with these studies, the proliferation, migration and invasion capacity of the BT549 and MDA-MB-231 triple-negative breast cancer cell lines are increased upon SETD7 knockdown. Here, SETD7 is linked to triple-negative breast carcinoma.