PDX1 and cancer: Pdx1 is also overexpressed in several cancers,168 such as pancreatic169 and gastric cancer.170 Pdx1 was first proposed to be a SETD7 substrate by Francis et al.171 Maganti et al. found that Pdx1 is methylated at K123 and K131 and that K131 is necessary for the Pdx1 transcriptional activity.