SETD7 and cancer: SETD7 also monomethylates H3K4 at the promoters of HIF-1α-activated genes, suggesting that SETD7 is involved in metabolic adaptation in hypoxic cancer cells.124,125 By contrast, another study showed that SETD7-mediated methylation of K32 negatively regulated HIF-1α transcriptional activity by preventing its binding to DNA, an effect that was reversed by (R)-PFI-2.126 Therefore, additional research must be conducted to clarify the effects of SETD7 on the function of HIF-1α.