SETD7 and neoplasm: Therefore, SETD7 may be a critical regulator of the FoxO3 tumor-suppressor activity, as well as FoxO3 ability to promote longevity.103,104,106,107 However, SETD7 also seems to methylate K270, which has opposite effects of those provoked by K271 methylation, preventing FoxO3 from binding to the promoter of the pro-apoptotic gene BIM in neuronal cells and preventing cell death.108