Zinc-finger DHHC domain-containing 8 (ZDHHC8) is an S-acyltransferase that mediates the reversible attachment of fatty acids onto cysteine residues (S-acylation), which regulates protein solubility, attachment to membranes, intracellular distribution, folding and stability.213,214 ZDHHC8 loss is associated with an increased risk of schizophrenia as ZDHHC8-knockout mice exhibit a deficit in prepulse inhibition.215 ZDHHC8 methylation by SETD7 occurs at K300. This evidence concerns the gene ZDHHC8 and schizophrenia.