SETD7 and breast carcinoma: Supporting this idea, the SETD7 expression levels were found to be increased in breast cancer patients with complete cancer remission in comparison with patients who suffered a recurrence.219 Understanding the context specificity of SETD7 can lead to substantial improvements in the way that we treat certain forms of breast cancer as the activation of SETD7 expression may be useful to prevent their transition into a CSC-like state, induce apoptosis or senescence and reduce steroid hormone receptor activity.