Furthermore, Cullin 1 was found to be upregulated in breast and gastric cancer, contributing to a poor prognostic due to increased cell proliferation, migration and invasion.74–76 Cullin 1 methylation by SETD7 occurs at K73, but further studies are needed to better understand and identify the SETD7 effects over Cullin 1 expression and function.30 The gene discussed is CUL1; the disease is gastric cancer.