Monopolar spindle 1 (MPS1, also known as TTK) phosphorylates numerous proteins that are involved in DNA damage-induced G2/M cell cycle arrest, spindle pole duplication and chromosome alignment and segregation during mitosis.207,208 MPS1 upregulation in cancers is associated with uncontrolled cell proliferation and increased tumor aggressiveness.207 MPS1 is (weakly) methylated by SETD7 at K708; however, the functional effects of this PTM still need to be established.30 The gene discussed is SETD7; the disease is cancer.