Hypoxia-inducible factor 1α (HIF-1α) is a transcriptional activator of genes that are involved in cell adaptation to low oxygen tension, altering energy metabolism and promoting angiogenesis to maintain tissue integrity and homeostasis.122 Under normal oxygen levels, HIF-1α is tightly regulated by the von Hippel-Lindau disease tumor suppressor (VHL) tumor suppressor, which induces ubiquitination-dependent proteasomal degradation of HIF-1α.123 SETD7 methylates HIF-1α at K32, which prevents K32 ubiquitination and HIF-1α degradation. Here, VHL is linked to neoplasm.