SETD7 and neoplasm: YY1 is overexpressed in cancer and functions as an oncogene by regulating genes that play a role in cancer development and progression, including C-MYC and TP53. 210,211 Intriguingly, some studies also reveal that YY1 might have a tumor-suppressive role in specific cases.211 YY1 is methylated by SETD7 at two lysine residues, K173 and K411, which regulate the affinity of YY1 to its consensus DNA-binding elements.