By contrast, SETD7 is overexpressed in hepatocellular carcinoma and some liver cancer cell lines, which correlates with a higher risk of metastasis and recurrence, large tumor size, cell proliferation and poor differentiation.223 Taken together, these results suggest that the SETD7 tumor-suppressor or oncogenic effects are dependent on each tumor driver’s alterations. This evidence concerns the gene SETD7 and hepatocellular carcinoma.