SETD7 and neoplasm: Interestingly, HOX can either be upregulated or downregulated in cancer and either have an oncogenic or a tumor-suppressor effect depending on the tissue context and cancer type.59–61 Although it is thought that H3K4 methylation at the promoters of HOX is mediated by mixed lieneage leukemia  methyltransferases, the possibility that SETD7 may also contribute to HOX transactivation has yet to be studied.49–51