SETD7 and cancer: However, it is unclear whether SETD7 is responsible for H3K4 methylation of these genes.7,48 One example of genes that are regulated by H3K4 methylation are HOX genes,49–51 which are mostly known for their role in embryonic development, coordinating tissue-specific cell growth, proliferation and differentiation.52–55 In adulthood, HOX regulates cell renewal,56 hematopoiesis,57 cell fate, differentiation and tissue homeostasis.55,58,59HOX expression dysregulation has been associated with cancer.