Pdx1 is also overexpressed in several cancers,168 such as pancreatic169 and gastric cancer.170 Pdx1 was first proposed to be a SETD7 substrate by Francis et al.171 Maganti et al. found that Pdx1 is methylated at K123 and K131 and that K131 is necessary for the Pdx1 transcriptional activity. The gene discussed is PDX1; the disease is gastric cancer.