Available studies revealed that SAP-induced AKI is mainly related to SIRS [9], which involves various cytokines and inflammatory mediators, such as nuclear factor kappa B (NF-B), tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, and high mobility group box protein 1(HMGB1) [11]. Here, HMGB1 is linked to acute kidney injury.