The elevated GAD Ab was likely related to autoimmune thyropathy, because the frequencies of GAD65 Ab and GAD67 Ab in toxic nodular goiter (a nonautoimmune form of hyperthyroidism) were lower [87] and modulations of TSH receptor antibodies level by carbimazole had no effect on the development of insulin autoantibodies [88]. The gene discussed is GAD2; the disease is hyperthyroidism.