In summary, we have provided an in-depth analysis of the importance of TF for progressive IH in a model of endoluminal injury in mice, first verifying the importance of TF for hyperplasia of CD31+ myofibrocytes and then defining the critical importance of angiopoietin-2 production, which appears necessary for proliferation, enhanced survival, and continued recruitment of neointimal cells. The gene discussed is ANGPT2; the disease is isolated hemihyperplasia.