MSH6 and immune system disorder: Accordingly, a potential conclusion of a higher degree of immunodeficiency in PMS2-deficient as compared to MSH6-deficient patients, as suggested by the findings in previous studies showing that three out of nine PMS2-deficient patients were symptomatic and needed IgG substitution, as compared to none out of eight MSH6-deficient individuals (16, 17), cannot be corroborated by our data.