PDCD1 and Miyoshi myopathy: Preliminary data in our lab indicate that PD-1 blockade of BM Vγ9Vδ2 T cells in MM could even worsen this polarization by inducing the expression of additional inhibitory molecules (FOXP3, CD73, CD39, and CD38) and the release of suppressive factors like IL-10 (Figure 2, option B).