FGF23 and chronic kidney disease: To further examine the interplay between FGF23 and its cardiac receptors Faul et al. also investigated the effect of FGF23 on FGFR4 null mice and found that abrogation of the FGFR4 prevented the development of LVH in vitro as well as in vivo while overexpression of FGFR4 induced LVH in non-CKD mice (21).