Later studies established the role of the adaptive immune response in hypertension after finding that mice with a genetic deletion in recombinase-activating protein (RAG-1−/−), which lack T- and B-lymphocytes, experience blunted hypertension in response to both Ang II and deoxycorticosterone acetate (DOCA)-salt; adoptive transfer of T-cells restored the elevation in BP (69). This evidence concerns the gene AGT and hypertensive disorder.