ADIPOQ and breast cancer: The MMTV-PyVT spontaneous mammary tumor mouse model with reduced adiponectin expressions facilitated breast tumor formation by downregulating mitogen-activated protein kinase (MAPK) 3 and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression and activating PI3K/Akt signaling (84, 85) and the phosphorylation of ERK 1/2 (86).