CSF-Progranulin (PGRN) and Neurofilament light chain (Nfl) are promising candidates as biomarkers for TDP-43 mediated neurodegeneration in Amyotrophic lateral sclerosis (3, 9) and are therefore interesting candidates in TDP-43 mediated FTD. This evidence concerns the gene NEFL and amyotrophic lateral sclerosis.