TARDBP and semantic dementia: In a subgroup of patients with semantic dementia (SD) histopathologically, Tar-DNA-Binding-Protein 43 (TDP-43) aggregates are the main characteristic of a subgroup of patients with semantic dementia (SD) (2), and pathomechanisms associated with dysfunctional TDP-43 or TDP-43 aggregates could play a major role in this form of the disease.