Overstimulation of CB1Rs by THC during this sensitive developmental period could interfere with normal CB1R-mediated developmental processes and the maturation of PFC GABAergic neurons, thereby leading to long-term dysfunction in prefrontal excitatory/inhibitory (Glutamate/GABA) balance, desynchronization of PFC neuronal networks, and deficits associated with schizoaffective disorders. The gene discussed is CNR1; the disease is schizoaffective disorder.