AKT1 and schizophrenia: In addition, we have observed long-term molecular alterations in several schizophrenia-related PFC signaling pathways, including profound reductions in the glycogen-synthase-kinase-3 (GSK-3), p70S6-kinase, Akt (protein kinase B), and mammalian target of rapamycin (mTOR) molecular phosphorylation cascades (122, 123), which have been consistently associated with dysregulation of DAergic function and neuropsychiatric disorders (108, 116, 133–136) (Figure 2).